Fecal microbiota transplant
Fecal microbiota transplantation (FMT) is the transfer of a well-balanced microbial community from a healthy donor to a patient suffering from intestinal dysbiosis. FMT is a physical transfer of stool samples, typically by using freeze-dried oral capsules. The transfer of such complete microbial ecosystem shows a high success in restoring gut health and hence is a promising treatment option for many chronic disorders.
Clostridium difficile treatment
Fecal microbiota transplantation appears to be an effective method for a permanent transfer of important fecal bacteria and other microbes and has been used to successfully treat Clostridium difficile infection in a long-term.
Risk of infections
Donors have to be screened carefully for risk markers, as there is a potential risk of serious infections with the use of fecal microbiota for transplantation
see → FDA Safety Alert 2020 of E.coli infections.
→ Nood 2013. Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
→ Li 2016. Durable coexistence of donor and recipient strains after fecal microbiota transplantation
→ Rinott 2020. Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain